Issue 20, 2022

Advancements in antimicrobial nanoscale materials and self-assembling systems


Antimicrobial resistance is directly responsible for more deaths per year than either HIV/AIDS or malaria and is predicted to incur a cumulative societal financial burden of at least $100 trillion between 2014 and 2050. Already heralded as one of the greatest threats to human health, the onset of the coronavirus pandemic has accelerated the prevalence of antimicrobial resistant bacterial infections due to factors including increased global antibiotic/antimicrobial use. Thus an urgent need for novel therapeutics to combat what some have termed the ‘silent pandemic’ is evident. This review acts as a repository of research and an overview of the novel therapeutic strategies being developed to overcome antimicrobial resistance, with a focus on self-assembling systems and nanoscale materials. The fundamental mechanisms of action, as well as the key advantages and disadvantages of each system are discussed, and attention is drawn to key examples within each field. As a result, this review provides a guide to the further design and development of antimicrobial systems, and outlines the interdisciplinary techniques required to translate this fundamental research towards the clinic.

Graphical abstract: Advancements in antimicrobial nanoscale materials and self-assembling systems

Article information

Article type
Review Article
30 May 2022
First published
03 Oct 2022
This article is Open Access
Creative Commons BY license

Chem. Soc. Rev., 2022,51, 8696-8755

Advancements in antimicrobial nanoscale materials and self-assembling systems

J. A. Doolan, G. T. Williams, K. L. F. Hilton, R. Chaudhari, J. S. Fossey, B. T. Goult and J. R. Hiscock, Chem. Soc. Rev., 2022, 51, 8696 DOI: 10.1039/D1CS00915J

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