A nanoscale polymolybdate built by two hexavacant Keggin-type fragments via a novel {Ca6P6O38} cluster with β-sheet conformation modulation ability

Jiai Hua; Xueman Wei; Yujian Bian; Xiang Ma; Li Hao; Jierui Sun; Jingjing Fan; Yulan Niu; Yanqing Wang

doi:10.1039/D2CE00215A

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

A nanoscale polymolybdate built by two hexavacant Keggin-type fragments via a novel {Ca₆P₆O₃₈} cluster with β-sheet conformation modulation ability†

Jiai Hua,

‡*^a Xueman Wei,‡^b Yujian Bian,‡^a Xiang Ma,

*^ac Li Hao,^d Jierui Sun,^a Jingjing Fan,^a Yulan Niu*^d and Yanqing Wang*^e

Author affiliations

* Corresponding authors

^a Department of Chemistry and Chemical Engineering, Taiyuan Institute of Technology, Taiyuan 030008, P. R. China
E-mail: jiaihua01660@163.com, maxiang@tit.edu.cn
Fax: +86 3513569476

^b Department of Geriatrics, First affiliated Hospital of Naval Medical University, Shanghai, P. R. China

^c State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing, P. R. China

^d Laboratory of Biochemistry and Pharmacy, Taiyuan Institute of Technology, Taiyuan, P. R. China
E-mail: Niuyl@tit.edu.cn

^e School of Chemistry and Environmental Engineering, Yancheng Teachers University, Yancheng City, P. R. China
E-mail: wangyanqing@yctu.edu.cn

Abstract

A novel sandwich-type phosphomolybdate based on two hexavacant Keggin-type building blocks [PMo₆O₂₈]¹⁵⁻ incorporating a novel hexagonal calcium phosphorus oxygen cluster {Ca₆P₆O₃₈} was successfully synthesized. It can modulate the β-sheet-rich misfolding conformation of Aβ that is believed to be the core structure of the toxic species in Alzheimer's disease and thus suppress the reactive oxygen species (ROS) produced by those harmful aggregates.

Download options Please wait...

Supplementary files

Article information

DOI: https://doi.org/10.1039/D2CE00215A
Article type: Communication
Submitted: 15 Feb 2022
Accepted: 14 Mar 2022
First published: 30 Mar 2022

Download Citation

CrystEngComm, 2022,24, 3153-3159

Permissions

Request permissions

A nanoscale polymolybdate built by two hexavacant Keggin-type fragments via a novel {Ca₆P₆O₃₈} cluster with β-sheet conformation modulation ability

J. Hua, X. Wei, Y. Bian, X. Ma, L. Hao, J. Sun, J. Fan, Y. Niu and Y. Wang, CrystEngComm, 2022, 24, 3153 DOI: 10.1039/D2CE00215A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

CrystEngComm