Issue 96, 2022
From the journal:

Chemical Communications

Proximity-driven bioorthogonal reactions via DNA circuits enable the accurate aptasensing of non-nucleic acid targets†

Su-Jing Zhao,a   Haiyu Guo,a   Zhenkun Wu ORCID logo *a  and  Jian-Hui Jiang ORCID logo a  

* Corresponding authors

a State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China
E-mail: tomwu@hnu.edu.cn

Abstract

Tetrazine-mediated bioorthogonal reactions were rationally coupled with DNA cascade circuits to enable proximal decaging, which allowed the construction of a fluorogenic aptasensor for the accurate and amplified sensing of non-nucleic acid targets in live cells.

Graphical abstract: Proximity-driven bioorthogonal reactions via DNA circuits enable the accurate aptasensing of non-nucleic acid targets

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Article information

DOI
https://doi.org/10.1039/D2CC05628C
Article type
Communication
Submitted
16 Oct 2022
Accepted
07 Nov 2022
First published
08 Nov 2022

Chem. Commun., 2022,58, 13393-13396

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Proximity-driven bioorthogonal reactions via DNA circuits enable the accurate aptasensing of non-nucleic acid targets

S. Zhao, H. Guo, Z. Wu and J. Jiang, Chem. Commun., 2022, 58, 13393 DOI: 10.1039/D2CC05628C

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