Mannobioside biomimetics that trigger DC-SIGN binding selectivity†
Antonio
di Maio, 
c
Javier
Rojo,
c
José M.
García Fernández,
c
Franck
Fieschi,
b
Pedro M.
Nieto
*c
and
Carmen
Ortiz Mellet
*a
c
Javier
Rojo,
c
José M.
García Fernández,
c
Franck
Fieschi,
b
Pedro M.
Nieto
*c
and
Carmen
Ortiz Mellet
*a
Abstract
Selective DC-SIGN targeting vs. langerin might lead to anti-infective agents, given their counteracting effects upon infection by some pathogens. Here we show that multivalent sp2-iminosugar-containing mannobioside analogs can achieve total DC-SIGN selectivity by levering the canonic binding mode towards high-mannose oligosaccharide ligands, behaving as factual biomimics.
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