An electrochemiluminescence dual “turn-on” strategy for alkaline phosphatase detection using a dual quenching Ru(bpy)32+ encapsulated zeolite imidazole metal organic framework

Chengpei Du; Yi Wang; Kanglin Pei; Di Wu; Wenjing Qi

doi:10.1039/D2CC04270C

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An electrochemiluminescence dual “turn-on” strategy for alkaline phosphatase detection using a dual quenching Ru(bpy)₃²⁺ encapsulated zeolite imidazole metal organic framework†

Chengpei Du,^a Yi Wang,^a Kanglin Pei,^a Di Wu^a and Wenjing Qi

*^a

Author affiliations

* Corresponding authors

^a Chongqing Key Laboratory of Inorganic Functional Materials, College of Chemistry, Chongqing Normal University, Chongqing, P. R. China
E-mail: wenjingqi616@cqnu.edu.cn

Abstract

An electrochemiluminescence dual “turn-on” strategy is first designed to detect alkaline phosphatase (ALP) using a dual quenching Ru(bpy)₃²⁺ encapsulated zeolite imidazole metal organic framework (Ru(bpy)₃²⁺@ZIF-90). Resonance energy transfer (ECRET) makes ECL “turn-off”. Ascorbic acid 2-phosphate is hydrolyzed into PO₄³⁻ and ascorbic acid (AA) by ALP. PO₄³⁻ decomposes Ru(bpy)₃²⁺@ZIF-90 and AA prevents ECRET, which makes ECL “turn-on” again.

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Article information

DOI: https://doi.org/10.1039/D2CC04270C
Article type: Communication
Submitted: 31 Jul 2022
Accepted: 05 Oct 2022
First published: 06 Oct 2022

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Chem. Commun., 2022,58, 12114-12117

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An electrochemiluminescence dual “turn-on” strategy for alkaline phosphatase detection using a dual quenching Ru(bpy)₃²⁺ encapsulated zeolite imidazole metal organic framework

C. Du, Y. Wang, K. Pei, D. Wu and W. Qi, Chem. Commun., 2022, 58, 12114 DOI: 10.1039/D2CC04270C

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Chemical Communications