An endoperoxide-containing covalent organic framework as a singlet oxygen reservoir for cancer therapy†
Abstract
A porphyrin-based COF containing a dialkylnaphthalene derivative was constructed to deliver extracellular singlet oxygen (1O2) into cancer cells through the Diels–Alder/retro-Diels–Alder reaction between dialkylnaphthalene and 1O2 to realize light- and oxygen-independent oxidative damage for cancer therapy.