A MnOx-nucleic acid nanoprobe with enzyme-free cascade signal amplification for ultrasensitive intracellular microRNA imaging

Jiayao Xu; Yuxin Qin; Qiuyi Liang; Xiaohong Zhong; Li Hou; Yong Huang; Shulin Zhao; Hong Liang

doi:10.1039/D2CC03980J

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A MnO_x-nucleic acid nanoprobe with enzyme-free cascade signal amplification for ultrasensitive intracellular microRNA imaging†

Jiayao Xu,‡^a Yuxin Qin,‡^a Qiuyi Liang,^a Xiaohong Zhong,^a Li Hou,

*^a Yong Huang,

*^a Shulin Zhao

^a and Hong Liang*^a

Author affiliations

* Corresponding authors

^a School of Chemistry and Pharmaceutical Sciences, State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin 541004, P. R. China
E-mail: houli@gxnu.edu.cn, huangyong_2009@163.com, hliang@gxnu.edu.cn

Abstract

A novel MnO_x-nucleic acid nanoprobe was constructed for catalytic imaging of microRNA in living cells based on the combination of catalytic hairpin assembly, hybridization chain reaction, and DNAzyme amplification. This nanoprobe exhibited ultrahigh sensitivity and specificity, and could distinguish tumor cells and normal cells by live cell microRNA imaging.

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Article information

DOI: https://doi.org/10.1039/D2CC03980J
Article type: Communication
Submitted: 16 Jul 2022
Accepted: 13 Oct 2022
First published: 25 Oct 2022

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Chem. Commun., 2022,58, 12883-12886

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A MnO_x-nucleic acid nanoprobe with enzyme-free cascade signal amplification for ultrasensitive intracellular microRNA imaging

J. Xu, Y. Qin, Q. Liang, X. Zhong, L. Hou, Y. Huang, S. Zhao and H. Liang, Chem. Commun., 2022, 58, 12883 DOI: 10.1039/D2CC03980J

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Chemical Communications