Issue 79, 2022
From the journal:

Chemical Communications

COF-based nanoreactors for click-activated prodrug delivery and precise anti-vascular therapy†

Peng Wang,*ab   Mili Li,a   Fang Zhou,ab   Yue Yang,a   Xia Yin,*a   Xiao-Bing Zhang ORCID logo a  and  Guosheng Song ORCID logo *a  

* Corresponding authors

a Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan 410082, China
E-mail: chemwangp@hnu.edu.cn, yinxia@hnu.edu.cn, songgs@hnu.edu.cn

b The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China

Abstract

Herein, we report a new click-activated prodrug, CA4V, and a bioorthogonal nanoreactor, CA4V/ZIF-90@TzCOF@Apt, which consists of a ZIF-90 core, tetrazine-based covalent organic framework (COF) shells and an aptamer polymer coating. When targeting a tumor, the acid-causing collapse of ZIF-90 initiates a nanoconfined bioorthogonal reaction in defined COF cages, which boosts the click efficiency of CA4V activation and therapeutic effects in vivo.

Graphical abstract: COF-based nanoreactors for click-activated prodrug delivery and precise anti-vascular therapy

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Article information

DOI
https://doi.org/10.1039/D2CC03931A
Article type
Communication
Submitted
14 Jul 2022
Accepted
01 Sep 2022
First published
02 Sep 2022

Chem. Commun., 2022,58, 11107-11110

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COF-based nanoreactors for click-activated prodrug delivery and precise anti-vascular therapy

P. Wang, M. Li, F. Zhou, Y. Yang, X. Yin, X. Zhang and G. Song, Chem. Commun., 2022, 58, 11107 DOI: 10.1039/D2CC03931A

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