Issue 65, 2022

Last-step 18F-fluorination of supported 2-(aryl-di-tert-butylsilyl)-N-methyl-imidazole conjugates for applications in positron emission tomography

Abstract

Aiming for potential applications in positron emission tomography, fully automated productions of 18F-labelled bioconjugates were achieved using heterogenous precursors obtained by anchoring imidazole-di-tert-butyl-arylsilanes to a polystyrene resin. The reactions were performed using either “batch” or “flow” procedures, avoiding both the time-consuming azeotropic drying and HPLC purifications usually required.

Graphical abstract: Last-step 18F-fluorination of supported 2-(aryl-di-tert-butylsilyl)-N-methyl-imidazole conjugates for applications in positron emission tomography

Supplementary files

Article information

Article type
Communication
Submitted
09 Jun 2022
Accepted
14 Jul 2022
First published
27 Jul 2022
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2022,58, 9140-9143

Last-step 18F-fluorination of supported 2-(aryl-di-tert-butylsilyl)-N-methyl-imidazole conjugates for applications in positron emission tomography

M. Steffann, M. Tisseraud, G. Bluet, S. Roy, C. Aubert, E. Fouquet and P. Hermange, Chem. Commun., 2022, 58, 9140 DOI: 10.1039/D2CC03258A

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