Issue 68, 2022
From the journal:

Chemical Communications

A cancer cell membrane vesicle-packaged DNA nanomachine for intracellular microRNA imaging†

Yuchao Chen,a   Wenhao Dai,*a   Dongdong Wangb  and  Haifeng Dong ORCID logo *ac  

* Corresponding authors

a Beijing Key Laboratory for Bioengineering and Sensing Technology, School of Chemistry and Bioengineering, University of Science and Technology Beijing, Beijing 100083, P. R. China
E-mail: wenhaodai@ustb.edu.cn

b Institute of regulatory science, Beijing Technology and Business University, Beijing 100048, P. R. China

c Marshall Laboratory of Biomedical Engineering, Research Center for Biosensor and Nanotheranostic, School of Biomedical Engineering, Health Science Center, Shenzhen University, Guangdong 518060, P. R. China
E-mail: hfdong@ustb.edu.cn

Abstract

A nanomachine consisting of cancer cell membrane vesicle-encapsulated gold nanoparticles with programmable DNA was established. Both homing-targeting ability and a fast dynamic response were achieved for amplification analysis of microRNAs in living cancer cells. The DNA nanomachine holds great potential to realize cancer diagnosis in early stages.

Graphical abstract: A cancer cell membrane vesicle-packaged DNA nanomachine for intracellular microRNA imaging

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Article information

DOI
https://doi.org/10.1039/D2CC03068C
Article type
Communication
Submitted
01 Jun 2022
Accepted
19 Jul 2022
First published
21 Jul 2022

Chem. Commun., 2022,58, 9488-9491

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A cancer cell membrane vesicle-packaged DNA nanomachine for intracellular microRNA imaging

Y. Chen, W. Dai, D. Wang and H. Dong, Chem. Commun., 2022, 58, 9488 DOI: 10.1039/D2CC03068C

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