Issue 47, 2022
From the journal:

Chemical Communications

A metal-organic framework@hydrogen-bond framework as a matrix for MALDI-TOF-MS analysis of small molecules†

Shi-Jun Yin,a   Guo-Can Zheng,b   Xin Yi,c   Guang-Ping Lvc  and  Feng-Qing Yang ORCID logo *a  

* Corresponding authors

a Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331, China
E-mail: fengqingyang@cqu.edu.cn

b Analytical and Testing Center, Chongqing University, Chongqing 401331, China

c School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, China

Abstract

A novel MOF@HOF composite that can serve as a matrix for analysis of small molecules by MALDI-TOF-MS was fabricated through a simple solvothermal method. Taking falvonoids as an example, this composite/matrix presents high desorption/ionization efficiency, low background interference, high salt tolerance, and satisfactory signal reproducibility for MALDI-TOF-MS analysis.

Graphical abstract: A metal-organic framework@hydrogen-bond framework as a matrix for MALDI-TOF-MS analysis of small molecules

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Article information

DOI
https://doi.org/10.1039/D2CC02206K
Article type
Communication
Submitted
19 Apr 2022
Accepted
11 May 2022
First published
11 May 2022

Chem. Commun., 2022,58, 6701-6704

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A metal-organic framework@hydrogen-bond framework as a matrix for MALDI-TOF-MS analysis of small molecules

S. Yin, G. Zheng, X. Yi, G. Lv and F. Yang, Chem. Commun., 2022, 58, 6701 DOI: 10.1039/D2CC02206K

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