Issue 45, 2022

Multi-pathway inducing ferroptosis by MnO2-based nanodrugs for targeted cancer therapy

Abstract

A multifunctional nanodrug (Tf–DHA–ASO–MnO2) based on manganese dioxide nanosheets was constructed by triple-dressing with transferrin, dihydroartemisinin, and antisense oligonucleotide sequences. Tf–DHA–ASO–MnO2 shows an effective targeted cancer therapy ability through the ferroptosis caused by the production of excessive lipid peroxides resulting from the combined effect of glutathione exhaustion, reactive oxygen species generation and down-regulation of glutathione peroxidase 4.

Graphical abstract: Multi-pathway inducing ferroptosis by MnO2-based nanodrugs for targeted cancer therapy

Supplementary files

Article information

Article type
Communication
Submitted
14 Apr 2022
Accepted
26 Apr 2022
First published
05 May 2022

Chem. Commun., 2022,58, 6486-6489

Multi-pathway inducing ferroptosis by MnO2-based nanodrugs for targeted cancer therapy

S. Fan, Q. Yang, Q. Song, M. Hong, X. Liu, H. Chen, J. Wang, C. Li and S. Cheng, Chem. Commun., 2022, 58, 6486 DOI: 10.1039/D2CC02134J

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