Confined microemulsion sono-polymerization of poly(ethylene glycol) nanoparticles for targeted delivery

Zhiliang Gao; Xiaoyu Li; Kaijie Zhao; Huimin Geng; Peiyu Zhang; Yi Ju; Pie Huda; Christopher B. Howard; Kristofer J. Thurecht; Muthupandian Ashokkumar; Jingcheng Hao; Jiwei Cui

doi:10.1039/D2CC01874H

Confined microemulsion sono-polymerization of poly(ethylene glycol) nanoparticles for targeted delivery†

Zhiliang Gao,

^ab Xiaoyu Li,^a Kaijie Zhao,

^a Huimin Geng,^a Peiyu Zhang,

^a Yi Ju,

^c Pie Huda,^de Christopher B. Howard,

^d Kristofer J. Thurecht,

^de Muthupandian Ashokkumar,

^f Jingcheng Hao

^a and Jiwei Cui

*^ab

Author affiliations

* Corresponding authors

^a Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Jinan, Shandong 250100, China
E-mail: jwcui@sdu.edu.cn

^b State Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong 266237, China

^c School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria 3083, Australia

^d Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St. Lucia, Queensland 4072, Australia

^e Centre for Advanced Imaging and ARC Training Centre for Innovation in Biomedical Imaging Technologies, The University of Queensland, St. Lucia, Queensland 4072, Australia

^f School of Chemistry, The University of Melbourne, Parkville, VIC 3010, Australia

Abstract

Confined sono-polymerization is developed to prepare poly(ethylene glycol) nanoparticles within water-in-oil microemulsion, followed by post-functionalization with a bispecific antibody (anti HER2 and anti PEG) for targeted delivery of photosensitizers (i.e., indocyanine green). The nanoparticles could specifically target to breast cancer cells (i.e., SKBR3) that overexpress HER2 receptors for the inhibition of cancer cell growth under 808 nm laser irradiation. This study highlights a facile and controllable method to fabricate therapeutic nanoparticles capable of targeted delivery.

Chemical Communications

Confined microemulsion sono-polymerization of poly(ethylene glycol) nanoparticles for targeted delivery†

Abstract

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Confined microemulsion sono-polymerization of poly(ethylene glycol) nanoparticles for targeted delivery

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