Two-photon fluorescence imaging of the cerebral peroxynitrite stress in Alzheimer's disease

Xilei Xie; Yawen Liu; Guangzhao Liu; Yuying Zhao; Jinyan Liu; Yong Li; Jian Zhang; Xiaoyun Jiao; Xu Wang; Bo Tang

doi:10.1039/D2CC01744J

Two-photon fluorescence imaging of the cerebral peroxynitrite stress in Alzheimer's disease†

Xilei Xie,^a Yawen Liu,^a Guangzhao Liu,^a Yuying Zhao,^a Jinyan Liu,^a Yong Li,^a Jian Zhang,^a Xiaoyun Jiao,^a Xu Wang*^a and Bo Tang

*^a

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* Corresponding authors

^a College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Shandong Normal University, Jinan 250014, P. R. China
E-mail: tangb@sdnu.edu.cn, wangxu@sdnu.edu.cn

Abstract

We designed and synthesized an oxindole-functionalized two-photon fluorescent probe based on a naphthalimide fluorophore, which enabled in situ visualization of the overwhelming peroxynitrite flux during amyloid-β-induced neuronal ferroptosis and cerebral peroxynitrite stress in live mice with Alzheimer's disease.

Chemical Communications

Two-photon fluorescence imaging of the cerebral peroxynitrite stress in Alzheimer's disease†

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Two-photon fluorescence imaging of the cerebral peroxynitrite stress in Alzheimer's disease

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