Issue 62, 2022
From the journal:

Chemical Communications

An active tumor-targeting organic photochemotherapy agent with naproxen for enhanced cancer therapy†

Chang Xu,‡a   Jinjie Chang,‡a   Yanhua Li,a   Kaiye Wang,a   Wei Pan, ORCID logo a   Hongyu Wang,*a   Na Li ORCID logo *a  and  Bo Tang ORCID logo *a  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan, P. R. China
E-mail: lina@sdnu.edu.cn, tangb@sdnu.edu.cn

Abstract

An active tumor-targeting organic photochemotherapy agent via the combination of a an organic photothermal material and a naproxen prodrug was developed to precisely kill cancer cells and suppress the inflammatory response induced by cell necrosis; in vitro, and in vivo experiments illustrated its low cytotoxicity and excellent tumor inhibitory effect.

Graphical abstract: An active tumor-targeting organic photochemotherapy agent with naproxen for enhanced cancer therapy

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Article information

DOI
https://doi.org/10.1039/D2CC01729F
Article type
Communication
Submitted
26 Mar 2022
Accepted
29 Jun 2022
First published
07 Jul 2022

Chem. Commun., 2022,58, 8682-8685

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An active tumor-targeting organic photochemotherapy agent with naproxen for enhanced cancer therapy

C. Xu, J. Chang, Y. Li, K. Wang, W. Pan, H. Wang, N. Li and B. Tang, Chem. Commun., 2022, 58, 8682 DOI: 10.1039/D2CC01729F

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