Issue 47, 2022
From the journal:

Chemical Communications

Simulation design of a binding-pocket structure of natural enzymes in MOFs for enhanced catalytic activity†

Weiran Zhu,a   Chen Chen,a   Zuorui Wen,a   Lijun Ding,a   Jie Wei,a   Jing Qian, ORCID logo a   Nan Hao*a  and  Kun Wang ORCID logo *a  

* Corresponding authors

a Key Laboratory of Modern Agriculture Equipment and Technology, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, Jiangsu, P. R. China
E-mail: hn@ujs.edu.cn, wangkun@ujs.edu.cn

Abstract

We demonstrated that the activity gap between metal–organic frameworks (Fe) and horseradish peroxidase could be bridged by simulating the binding-pocket structure and adding active centers. This customized structure promoted the activation and enrichment of substrates, and addition of gold nanoparticles led to activity superposition and synergistic enhancement.

Graphical abstract: Simulation design of a binding-pocket structure of natural enzymes in MOFs for enhanced catalytic activity

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Article information

DOI
https://doi.org/10.1039/D2CC01634F
Article type
Communication
Submitted
22 Mar 2022
Accepted
10 May 2022
First published
11 May 2022

Chem. Commun., 2022,58, 6745-6748

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Simulation design of a binding-pocket structure of natural enzymes in MOFs for enhanced catalytic activity

W. Zhu, C. Chen, Z. Wen, L. Ding, J. Wei, J. Qian, N. Hao and K. Wang, Chem. Commun., 2022, 58, 6745 DOI: 10.1039/D2CC01634F

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