Issue 39, 2022

Iridium-catalyzed chemoselective asymmetric hydrogenation of conjugated enones with ferrocene-based multidentate phosphine ligands

Abstract

A series of novel and readily prepared ferrocene-based multidentate phosphine ligands (f-PNNO) have been developed and successfully used in iridium-catalyzed enantioselective 1,2-reduction of α,β-unsaturated ketones, delivering chiral allylic alcohols in high yields and high enantioselectivities (up to 99% yield and up to 99% ee). Furthermore, the gram scale reaction proceeded very smoothly with 0.001 mol% catalyst loading, which indicated that the newly developed Ir/f-PNNO catalytic system has excellent activity in asymmetric hydrogenation of conjugated enones.

Graphical abstract: Iridium-catalyzed chemoselective asymmetric hydrogenation of conjugated enones with ferrocene-based multidentate phosphine ligands

Supplementary files

Article information

Article type
Communication
Submitted
19 Mar 2022
Accepted
13 Apr 2022
First published
13 Apr 2022

Chem. Commun., 2022,58, 5841-5844

Iridium-catalyzed chemoselective asymmetric hydrogenation of conjugated enones with ferrocene-based multidentate phosphine ligands

J. Ma, W. Li, L. He and H. Lv, Chem. Commun., 2022, 58, 5841 DOI: 10.1039/D2CC01583H

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