Issue 27, 2022
From the journal:

Chemical Communications

Chiral rhodium(iii)–azobenzene complexes as photoswitchable DNA molecular locks†

Mingwei Lin,‡a   Shanshan Zou,‡a   Tingzhen Li,a   Johannes Karges, ORCID logo b   Yu Chen, ORCID logo *a   Yukun Zhao,*c   Liangnian Jia  and  Hui Chao ORCID logo *a  

* Corresponding authors

a MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, P. R. China
E-mail: ceschh@mail.sysu.edu.cn, chenyu63@mail.sysu.edu.cn

b Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA

c Department of Dermatology, The Eastern Division of the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, P. R. China
E-mail: zhaoyukun7288569@sina.com

Abstract

Chiral rhodium(III)–azobenzene complexes that are able to intercalate into DNA were developed. Upon light exposure, the azobenzene moiety of the metal complexes can photoisomerize from the trans-form to the cis-form, and strongly stabilize the DNA double-helix and modulate DNA transcription. This study presents the first example of metal-based photoswitchable DNA molecular locks.

Graphical abstract: Chiral rhodium(iii)–azobenzene complexes as photoswitchable DNA molecular locks

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Article information

DOI
https://doi.org/10.1039/D2CC00932C
Article type
Communication
Submitted
15 Feb 2022
Accepted
02 Mar 2022
First published
02 Mar 2022

Chem. Commun., 2022,58, 4324-4327

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Chiral rhodium(III)–azobenzene complexes as photoswitchable DNA molecular locks

M. Lin, S. Zou, T. Li, J. Karges, Y. Chen, Y. Zhao, L. Ji and H. Chao, Chem. Commun., 2022, 58, 4324 DOI: 10.1039/D2CC00932C

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