We report DNA-catalysed alternative RNA splicing in vitro. Using modular DNA catalysts with RNA endonuclease and RNA ligase activities, we show that DNA can modulate RNA structure and activity. Furthermore, we illustrate that such DNA-catalysed reactions can yield, from a common precursor, different splicing isoforms with distinct functions.
D. Wei, M. Gao, J. Guo, Y. Wang, X. Li, Z. Li and H. Yu, Chem. Commun., 2022, 58, 7698 DOI: 10.1039/D2CC00812B
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