Sustained-release nanocapsule based on a 3D COF for long-term enzyme prodrug therapy of cancer

Xiuyan Wan; Jiaqi Yin; Qianqian Yan; Hui Hu; Teng Zheng; Yuying Chai; Wei Pan; Yanan Gao; Na Li; Bo Tang

doi:10.1039/D2CC00373B

Sustained-release nanocapsule based on a 3D COF for long-term enzyme prodrug therapy of cancer†

Xiuyan Wan,‡^a Jiaqi Yin,‡^a Qianqian Yan,‡^b Hui Hu,^b Teng Zheng,^a Yuying Chai,^b Wei Pan,

^a Yanan Gao,*^b Na Li

*^a and Bo Tang

*^a

Author affiliations

* Corresponding authors

^a College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China
E-mail: lina@sdnu.edu.cn, tangb@sdnu.edu.cn

^b Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources, Hainan University, No. 58, Renmin Avenue, Haikou 570228, P. R. China
E-mail: ygao@hainanu.edu.cn

Abstract

A well-designed three-dimensional (3D) covalent organic framework (COF) was constructed as a nanocapsule for the encapsulation of horseradish peroxidase (HRP), which could realize sustained release of HRP to prolong the duration of the therapeutic agents and promote long-term enzyme prodrug therapy.

Chemical Communications

Sustained-release nanocapsule based on a 3D COF for long-term enzyme prodrug therapy of cancer†

Abstract

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Sustained-release nanocapsule based on a 3D COF for long-term enzyme prodrug therapy of cancer

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