Issue 23, 2022
From the journal:

Chemical Communications

Design and development of selective competitive fluorescent ligands for the detection and visualization of Kv7.2/7.3 in vitro†

Zhen Qiao,‡a   Siyuan Tang,‡a   Jialiang Guan,‡c   Zhengji Yin,d   Chao Zhu,e   Qiqi Zhou*b  and  Liming Shao ORCID logo *a  

* Corresponding authors

a Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China
E-mail: limingshao@fudan.edu.cn

b Department of Pharmacology, Qilu Medical University, Zibo, Shandong 255300, China
E-mail: zqqqingdao@126.com

c The Department of Emergency Internal Medicine, The Affiliated Hospital of Qingdao University, Shandong 266001, China

d Departments of Pharmacology, School of Pharmacy, Qingdao University Medical College, #1 Ningde Road, Qingdao 266073, China

e The Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Shandong 266001, China

Abstract

A series of specific and potent fluorescent ligands were developed for labelling and visualizing Kv7.2/7.3 based molecular rotation restriction. Probes 21b and 24a were found to be safe and convenient tools to detect and visualize Kv7.2/7.3 in live cells and mouse brain tissue.

Graphical abstract: Design and development of selective competitive fluorescent ligands for the detection and visualization of Kv7.2/7.3 in vitro

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Article information

DOI
https://doi.org/10.1039/D2CC00372D
Article type
Communication
Submitted
19 Jan 2022
Accepted
20 Feb 2022
First published
21 Feb 2022

Chem. Commun., 2022,58, 3791-3794

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Design and development of selective competitive fluorescent ligands for the detection and visualization of Kv7.2/7.3 in vitro

Z. Qiao, S. Tang, J. Guan, Z. Yin, C. Zhu, Q. Zhou and L. Shao, Chem. Commun., 2022, 58, 3791 DOI: 10.1039/D2CC00372D

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