Issue 28, 2022
From the journal:

Chemical Communications

Probing the flux of mitochondrial potassium using an azacrown-diketopyrrolopyrrole based highly sensitive probe†

G. Dinesh Kumar,a   Marzena Banasiewicz,b   Antoni Wrzosek,c   Rafal P. Kampa, ORCID logo c   Manon H. E. Bousquet, ORCID logo d   Damian Kusy,a   Denis Jacquemin, ORCID logo *d   Adam Szewczyk*c  and  Daniel T. Gryko ORCID logo *a  

* Corresponding authors

a Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland
E-mail: dtgryko@icho.edu.pl

b Institute of Physics, Polish Academy of Sciences, Al. Lotników 32/46, 02-668 Warsaw, Poland

c Nencki Institute of Experimental Biology of Polish Academy of Sciences, Pasteur 3, 02-093 Warsaw, Poland
E-mail: a.szewczyk@nencki.gov.pl

d University of Nantes, CNRS, CEISAM, UMR-6230, F-4400 Nantes, France
E-mail: Denis.Jacquemin@univ-nantes.fr

Abstract

The diketopyrrolopyrrole bearing an aza-18-crown-6 as a binding unit as well as a PPh3+ group is highly sensitive towards K+ and localizes selectively in mitochondria of cardiac H9C2 cells. Fast efflux/influx of mitochondrial K+ can be observed upon stimulation with nigericin.

Graphical abstract: Probing the flux of mitochondrial potassium using an azacrown-diketopyrrolopyrrole based highly sensitive probe

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Article information

DOI
https://doi.org/10.1039/D2CC00324D
Article type
Communication
Submitted
17 Jan 2022
Accepted
09 Mar 2022
First published
09 Mar 2022

Chem. Commun., 2022,58, 4500-4503

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Probing the flux of mitochondrial potassium using an azacrown-diketopyrrolopyrrole based highly sensitive probe

G. D. Kumar, M. Banasiewicz, A. Wrzosek, R. P. Kampa, M. H. E. Bousquet, D. Kusy, D. Jacquemin, A. Szewczyk and D. T. Gryko, Chem. Commun., 2022, 58, 4500 DOI: 10.1039/D2CC00324D

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