Issue 26, 2022

Transfer hydrogenation of pyridinium and quinolinium species using ethanol as a hydrogen source to access saturated N-heterocycles

Abstract

Catalytic transfer hydrogenation (TH) for the reduction of heterocycles is an emerging strategy for accessing biologically active saturated N-heterocycles. Herein, we report a TH protocol that utilizes ethanol as a renewable hydrogen source and an Ir catalyst for the reduction of quinolines and pyridines. The reaction is promoted by simple amides as ligands.

Graphical abstract: Transfer hydrogenation of pyridinium and quinolinium species using ethanol as a hydrogen source to access saturated N-heterocycles

Supplementary files

Article information

Article type
Communication
Submitted
14 Jan 2022
Accepted
08 Mar 2022
First published
08 Mar 2022

Chem. Commun., 2022,58, 4255-4258

Transfer hydrogenation of pyridinium and quinolinium species using ethanol as a hydrogen source to access saturated N-heterocycles

S. Yadav, D. Chaudhary, N. K. Maurya, D. Kumar, K. Ishu and M. R. Kuram, Chem. Commun., 2022, 58, 4255 DOI: 10.1039/D2CC00241H

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