Issue 25, 2022

Merging C–C σ-bond activation of cyclobutanones with CO2 fixation via Ni-catalysis

Abstract

A carboxylative Ni-catalyzed tandem C–C σ-bond activation of cyclobutanones followed by CO2-electrophilic trapping is documented as a direct route to synthetically valuable 3-indanone-1-acetic acids. The protocol shows an adequate functional group tolerance and useful chemical outcomes (yield up to 76%) when AlCl3 is adopted as an additive. Manipulations of the targeted cyclic scaffolds and a mechanistic proposal based on experimental evidence complete the investigation.

Graphical abstract: Merging C–C σ-bond activation of cyclobutanones with CO2 fixation via Ni-catalysis

Supplementary files

Article information

Article type
Communication
Submitted
10 Jan 2022
Accepted
25 Feb 2022
First published
25 Feb 2022
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2022,58, 4071-4074

Merging C–C σ-bond activation of cyclobutanones with CO2 fixation via Ni-catalysis

L. Lombardi, A. Cerveri, L. Ceccon, R. Pedrazzani, M. Monari, G. Bertuzzi and M. Bandini, Chem. Commun., 2022, 58, 4071 DOI: 10.1039/D2CC00149G

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