Enantioselective reaction of N-cyano imines: decarboxylative Mannich-type reaction with malonic acid half thioesters

Abstract

The enantioselective reaction of imines bearing a cyano group as an activating group with malonic acid half thioesters gave chiral cyanamide derivatives with high enantioselectivity. The density functional theory (DFT) calculation clarified the stereochemical outcome and importance of the N-cyano group for imines.