GuRhaGT, a highly specific saponin 2′′-O-rhamnosyltransferase from Glycyrrhiza uralensis

Zi-Long Wang; Jia-Jing Zhou; Bo-Yun Han; Aobulikasimu Hasan; Ya-Qun Zhang; Jia-He Zhang; Hai-Dong Wang; Bin Li; Xue Qiao; Min Ye

doi:10.1039/D1CC07021E

GuRhaGT, a highly specific saponin 2′′-O-rhamnosyltransferase from Glycyrrhiza uralensis†

Zi-Long Wang,

‡^a Jia-Jing Zhou,‡^a Bo-Yun Han,‡^a Aobulikasimu Hasan,^a Ya-Qun Zhang,

^a Jia-He Zhang,^a Hai-Dong Wang,^a Bin Li,

^a Xue Qiao

*^a and Min Ye

*^abc

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* Corresponding authors

^a State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China
E-mail: qiaoxue@bjmu.edu.cn, yemin@bjmu.edu.cn

^b Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, Peking University, 38 Xueyuan Road, Beijing 100191, China

^c Peking University-Yunnan Baiyao International Medical Research Center, 38 Xueyuan Road, Beijing 100191, China

Abstract

A highly regio- and donor-specific 2′′-O-rhamnosyltransferase GuRhaGT was characterised from the medicinal plant Glycyrrhiza uralensis. GuRhaGT could efficiently catalyse rhamnosylation at 2′′-OH of the C-3 glycosyl moiety of triterpenoid saponins.

Chemical Communications

GuRhaGT, a highly specific saponin 2′′-O-rhamnosyltransferase from Glycyrrhiza uralensis†

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GuRhaGT, a highly specific saponin 2′′-O-rhamnosyltransferase from Glycyrrhiza uralensis

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