Silver oxide(i) promoted Conia-ene/radical cyclization for a straightforward access to furan derivatives

Abstract

A novel access to fused furan cores using silver oxide(I) has been developed. Mechanistic investigations indicate the involvement of a Conia-ene reaction/radical cyclization for an expedient path to complex furan derivatives. The reaction is broad in scope with interesting atom economy and can also be conducted in a one-pot fashion from readily accessible α,β-unsaturated ketones.