Issue 12, 2022
From the journal:

Chemical Communications

Chemoproteomic profiling reveals celastrol as a potential modulator of cholesterol signaling†

Yiyun Geng,a   Jingyuan Xu,a   Weichao Li,b   Qing Li,ac   Chenjinxin Shen,a   Zhangshuang Dengc  and  Yiqing Zhou ORCID logo *ab  

* Corresponding authors

a School of Biotechnology and Food Engineering, Changshu Institute of Technology, Suzhou 215500, China
E-mail: zhyq2012@gmail.com

b CAS Key Laboratory of Synthetic Biology, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China

c College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China

Abstract

We report a quantitative chemoproteomic approach that utilizes a clickable photoreactive probe for global profiling of celastrol targets, which may significantly improve the current understanding of celastrol's mode of action.

Graphical abstract: Chemoproteomic profiling reveals celastrol as a potential modulator of cholesterol signaling

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Article information

DOI
https://doi.org/10.1039/D1CC05986F
Article type
Communication
Submitted
24 Oct 2021
Accepted
06 Jan 2022
First published
07 Jan 2022

Chem. Commun., 2022,58, 1914-1917

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Chemoproteomic profiling reveals celastrol as a potential modulator of cholesterol signaling

Y. Geng, J. Xu, W. Li, Q. Li, C. Shen, Z. Deng and Y. Zhou, Chem. Commun., 2022, 58, 1914 DOI: 10.1039/D1CC05986F

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