Issue 11, 2022

A guide to direct mechanocatalysis


Direct mechanocatalysis (DM) describes solvent-free catalytic reactions that are initiated by mechanical forces in mechanochemical reactors such as ball mills. The distinctive feature of DM is that the milling materials, e.g. the milling balls themselves are the catalyst of the reaction. In this article we follow the historical evolution of this novel concept and give a guide to this emerging, powerful synthesis tool. Within this perspective we seek to highlight the impact of the relevant milling parameters, the nature of the catalyst and potential additives, the scope of reactions that are currently accessible by this method, and the thus far raised hypotheses on the underlying mechanisms of direct mechanochemical transformations.

Graphical abstract: A guide to direct mechanocatalysis

Article information

Article type
Feature Article
08 Oct 2021
06 Dec 2021
First published
13 Jan 2022
This article is Open Access
Creative Commons BY license

Chem. Commun., 2022,58, 1661-1671

A guide to direct mechanocatalysis

S. Hwang, S. Grätz and L. Borchardt, Chem. Commun., 2022, 58, 1661 DOI: 10.1039/D1CC05697B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity