An upgraded 2D nanosheet-based FRET biosensor: insights into avoiding background and eliminating effects of background fluctuations

Suli Jia; Chengquan Wang; Jing Qian; Xingcai Zhang; Haining Cui; Qi Zhang; Yunmeng Tian; Nan Hao; Jie Wei; Kun Wang

doi:10.1039/D1CC05429E

An upgraded 2D nanosheet-based FRET biosensor: insights into avoiding background and eliminating effects of background fluctuations†

Suli Jia,‡^a Chengquan Wang,

‡^b Jing Qian,

*^a Xingcai Zhang,

^cd Haining Cui,^a Qi Zhang,^a Yunmeng Tian,^a Nan Hao,^a Jie Wei^a and Kun Wang

*^a

Author affiliations

* Corresponding authors

^a School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, P. R. China
E-mail: qianj@ujs.edu.cn, wangkun@ujs.edu.cn

^b School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, P. R. China

^c School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA

^d School of Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA

Abstract

We demonstrated a new class of 2D nanosheet-based FRET biosensor utilizing vertically oriented MoS₂ nanosheets on a magnetic nanocarrier. Compared with the non-separated biosensor under identical conditions, this upgraded one can avoid the background signal of the system and eliminate the effects of background fluctuations, which produces more excellent detection methods.

Chemical Communications

An upgraded 2D nanosheet-based FRET biosensor: insights into avoiding background and eliminating effects of background fluctuations†

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An upgraded 2D nanosheet-based FRET biosensor: insights into avoiding background and eliminating effects of background fluctuations

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