Issue 21, 2022

Interconversion between [2Fe–2S] and [4Fe–4S] cluster glutathione complexes

Abstract

We present here how different iron–sulfide–glutathione ratios, applied in in vitro conditions comparable to those present in the mitochondrial matrix, affect the speciation of iron–sulfur cluster glutathione complexes. An excess of sulfide with respect to iron ions promotes the formation of a tetranuclear [FeII2FeIII2S4(GS)4]2− complex, while an excess of iron ions favors the formation of a dinuclear [FeIIFeIIIS2(GS)4]3− complex. These two complexes establish an interconversion equilibrium. The latter might play a role in the composition of the mitochondrial labile iron pool potentially contributing to the regulation of cellular iron homeostasis.

Graphical abstract: Interconversion between [2Fe–2S] and [4Fe–4S] cluster glutathione complexes

Supplementary files

Article information

Article type
Communication
Submitted
06 Jul 2021
Accepted
10 Feb 2022
First published
15 Feb 2022
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2022,58, 3533-3536

Interconversion between [2Fe–2S] and [4Fe–4S] cluster glutathione complexes

M. Invernici, G. Selvolini, J. M. Silva, G. Marrazza, S. Ciofi-Baffoni and M. Piccioli, Chem. Commun., 2022, 58, 3533 DOI: 10.1039/D1CC03566E

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