Issue 12, 2022
From the journal:

Biomaterials Science

An autophagy-inhibitory MOF nanoreactor for tumor-targeted synergistic therapy†

Xiaohan Liu,‡a   Peng Gao, ORCID logo ‡a   Mingwan Shi,a   Yuanyuan Chen,a   Wei Pan, ORCID logo a   Na Li ORCID logo *a  and  Bo Tang ORCID logo a  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China
E-mail: lina@sdnu.edu.cn

Abstract

An autophagy-inhibitory metal–organic framework (MOF) nanoreactor was developed for tumor-targeted synergistic therapy. The nanoreactor could inhibit autophagy to enhance the glucose oxidase (GOx)-mediated starvation therapy. The H2O2 generated in this process induced the polarization of macrophages to the M1 phenotype, which further enhanced the therapeutic effect.

Graphical abstract: An autophagy-inhibitory MOF nanoreactor for tumor-targeted synergistic therapy

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Article information

DOI
https://doi.org/10.1039/D2BM00579D
Article type
Communication
Submitted
13 Apr 2022
Accepted
16 May 2022
First published
19 May 2022

Biomater. Sci., 2022,10, 3088-3091

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An autophagy-inhibitory MOF nanoreactor for tumor-targeted synergistic therapy

X. Liu, P. Gao, M. Shi, Y. Chen, W. Pan, N. Li and B. Tang, Biomater. Sci., 2022, 10, 3088 DOI: 10.1039/D2BM00579D

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