Imidazole ionic liquid functionalized ZIF-67 molecularly imprinted solid-phase extraction coupled with high performance liquid chromatography for analysis of bisphenol A

Abstract

An effective method based on an imidazole ionic liquid functionalized ZIF-67 molecularly imprinted solid-phase extractant (ZIF-67@[Bmim][Br]@MIP) coupled with high performance liquid chromatography (HPLC) for the separation/analysis of bisphenol A (BPA) was established. ZIF-67@[Bmim][Br]@MIP was characterized by FTIR, XRD, SEM, TEM and BET. Several important factors, such as pH, amount of extractant, extraction time, and types of eluents were investigated in detail. Under the optimal conditions, the linear range of the method was 0.01–20.00 μg mL⁻¹, the detection limit was 5.0 ng mL⁻¹, and the linear correlation was good (R² = 0.9994). The detection of BPA in mineral water bottles, milk cartons and milk tea cups proved that the method was simple and effective, and could be used to separate and analyze BPA in real samples.