Issue 2, 2022

Manganese-doped iron coordination polymer nanoparticles with enhanced peroxidase-like activity for colorimetric detection of antioxidants

Abstract

A convenient and sensitive antioxidant assay with high performance is essential for assessing food quality and monitoring the oxidative stress level of biological matrices. Although coordination polymer nanoparticles (CPNs)-based nanozymes have emerged as candidates in the analytical field, strategies to improve the catalytic activity of CPNs have been scarcely revealed and studied. Herein, we demonstrate a manganese (Mn) doping strategy to enhance the peroxidase-mimetic activity of Fe-based CPNs. By tuning the Mn doping amounts and selecting 2,5-dihydroxyterephthalic acid (H4DHTP) as ligands, the produced nanozymes in amorphous state followed the catalytic activity order of Fe5Mn-DHTP > Fe8Mn-DHTP > Fe2Mn-DHTP > Fe-DHTP > Mn-DHTP. Ulteriorly, benefitting from the best catalytic performance and definite catalytic mechanism of Fe5Mn-DHTP, versatile colorimetric assays for ultrasensitive detection of one exogenous antioxidant (ascorbic acid, AA) and two endogenous antioxidants (glutathione, GSH; cysteine, Cys) have been deftly devised based on the inhibition of the 3,3′,5,5′-tetramethylbenzidine chromogenic reaction in presence of H2O2. It was found that mercaptan (GSH and Cys) and AA exhibited different inhibition mechanisms. Practically, such a colorimetric assay was viable to determine the total antioxidant capacity of drugs and foods with desirable results. This work proposes a feasible strategy for embellishing CPN nanozymes used for designing sensitive and convenient assays for various antioxidants based on an explicit detection mechanism.

Graphical abstract: Manganese-doped iron coordination polymer nanoparticles with enhanced peroxidase-like activity for colorimetric detection of antioxidants

Supplementary files

Article information

Article type
Paper
Submitted
29 Oct 2021
Accepted
29 Nov 2021
First published
30 Nov 2021

Analyst, 2022,147, 238-246

Manganese-doped iron coordination polymer nanoparticles with enhanced peroxidase-like activity for colorimetric detection of antioxidants

C. Zhang, X. Zhang, Y. Ye, P. Ni, C. Chen, W. Liu, B. Wang, Y. Jiang and Y. Lu, Analyst, 2022, 147, 238 DOI: 10.1039/D1AN01953H

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