Bulk-heterojunction photocapacitors with high open-circuit voltage for low light intensity photostimulation of neurons

Abstract

High-level transduction control of light to bioelectricity is an important goal for the realization of superior neuron-device interfaces that can be used for regulating fundamental cellular processes to cure neurological disorders. In this study, a single-junction, wireless, and capacitive-charge-injecting optoelectronic biointerface with negligible faradaic reactions by using a high open-circuit voltage (0.75 V) bulk heterojunction of PTB7-Th:PC71BM is designed and demonstrated. The biointerface generates a 2-fold higher photocurrent in comparison with P3HT:PC61BM having an open-circuit voltage of 0.55 V. Furthermore, we observed that light intensity is logarithmically correlated with the open-circuit voltage of solar cells, and the photovoltage of the biointerfaces varies the switching speed of capacitive charge-transfer. Finally, pulse trains of capacitive stimuli at a low light intensity of 20 mW cm⁻² elicit action potential generation in primary hippocampal neurons extracted from E15–E17 Wistar Albino rats. These findings show the great promise of high open-circuit voltage bulk heterojunction biointerfaces for non-genetic, all-optical and safe modulation of neurons.