Issue 26, 2021

Photothermal treatment of oropharyngeal cancer with carbon-defective silicon carbide

Abstract

Oral squamous carcinoma (OSCC) is a clinical common tumor with high recurrence rate and low 5 year survival rate. In this work, photothermal antitumor treatment has been performed to treat OSCC by taking anti-wound infection into consideration. By introducing C defects, we have successfully converted the semi-conductive SiC into metallic carbon-defective silicon carbide (SiC1−x), and endowed it with the near infrared absorption property for photothermal therapy (PTT). The results revealed that SiC1−x mediated PTT treatment could remove solid OSCC tumor in a biosafe way, showing low hematotoxicity, cytotoxicity and tissue toxicity. Moreover, the low invasion of PTT treatment could not only prevent the invasion of bacteria, but also realize an antibacterial effect on the wound, both of which are important for oral surgery. SiC1−x could be excreted from the body post treatment, which thus reduces the long-term potential toxicity. On the whole, this study provided a promising way to treat OSCC in an effective and safe way.

Graphical abstract: Photothermal treatment of oropharyngeal cancer with carbon-defective silicon carbide

Supplementary files

Article information

Article type
Paper
Submitted
19 Apr 2021
Accepted
04 Jun 2021
First published
05 Jun 2021

J. Mater. Chem. B, 2021,9, 5284-5292

Photothermal treatment of oropharyngeal cancer with carbon-defective silicon carbide

H. Mu, H. Pang, C. Zheng, K. Wang, N. Hu and B. Zhang, J. Mater. Chem. B, 2021, 9, 5284 DOI: 10.1039/D1TB00876E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements