Issue 16, 2021

Systematic study of SYBR green chromophore reveals major improvement with one heteroatom difference

Abstract

Five nucleic acid binding cyanine dyes were synthesized and their photophysical properties were evaluated. Changing a single heteroatom in the chromophore causes major differences both in brightness and photostability between the dyes. With such alteration, the brightness of the chromophore increased two-fold compared to the one found in SYBR Green I.

Graphical abstract: Systematic study of SYBR green chromophore reveals major improvement with one heteroatom difference

Supplementary files

Article information

Article type
Communication
Submitted
15 Feb 2021
Accepted
07 Apr 2021
First published
08 Apr 2021
This article is Open Access
Creative Commons BY-NC license

J. Mater. Chem. B, 2021,9, 3484-3488

Systematic study of SYBR green chromophore reveals major improvement with one heteroatom difference

V. K. Saarnio, J. M. Alaranta and T. M. Lahtinen, J. Mater. Chem. B, 2021, 9, 3484 DOI: 10.1039/D1TB00312G

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