Issue 13, 2021

Intravital NIR-II three-dimensional photoacoustic imaging of biomineralized copper sulfide nanoprobes

Abstract

Photoacoustic (PA) imaging with functional nanoprobes in the second near-infrared region (NIR-II, 1000–1700 nm) has aroused much interest due to its deep tissue penetration and high maximum laser permissible exposure. However, most NIR-II PA imaging is performed using the two-dimensional (2D) imaging modality, which impedes the comprehension of the in vivo biodistribution, angiography and molecular-targeted performance of NIR-II nanoprobes (NPs). Herein, we report the systematic monitoring of biomineralized copper sulfide (CuS) NPs, typical NIR-II NPs, in mouse models by employing NIR-II three-dimensional (3D) PA imaging. The advanced imaging modality provides dynamic information about the 3D biodistribution and metabolic pathway of CuS NPs. We also achieved contrast-enhanced 3D PA imaging of abdominal and cerebral vessels at a high signal-to-background ratio. Moreover, the tumor-targeted CuS NPs conjugated with the bombesin peptide endowed NIR-II 3D PA with superior performance in imaging orthotopic tumors both deep in the prostate and in the brain beneath the intact scalp and skull. Our results highlight the potential of NIR-II 3D PA imaging for the evaluation of the in vivo behavior of NPs, thus providing a promising strategy for screening NPs in clinical translational studies.

Graphical abstract: Intravital NIR-II three-dimensional photoacoustic imaging of biomineralized copper sulfide nanoprobes

Supplementary files

Article information

Article type
Paper
Submitted
30 Dec 2020
Accepted
20 Feb 2021
First published
11 Mar 2021

J. Mater. Chem. B, 2021,9, 3005-3014

Intravital NIR-II three-dimensional photoacoustic imaging of biomineralized copper sulfide nanoprobes

H. Zhou, J. Ren, Y. Lin, D. Gao, D. Hu, T. Yin, C. Qiu, X. Miao, C. Liu, X. Liu, H. Zheng, R. Zheng and Z. Sheng, J. Mater. Chem. B, 2021, 9, 3005 DOI: 10.1039/D0TB03010D

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