A class of water-soluble Fe(III) coordination complexes as T1-weighted MRI contrast agents

Run Wang; Lu An; Jing He; Mengmeng Li; Jingjing Jiao; Shiping Yang

doi:10.1039/D0TB02716B

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A class of water-soluble Fe(iii) coordination complexes as T₁-weighted MRI contrast agents†

Run Wang,^a Lu An,

^a Jing He,^a Mengmeng Li,^a Jingjing Jiao*^a and Shiping Yang

*^ab

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* Corresponding authors

^a Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, China
E-mail: jiaojj@shnu.edu.cn, shipingy@shnu.edu.cn

^b The Key Laboratory of Resource Chemistry of the Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai 200234, P. R. China

Abstract

Iron-based coordination complexes are showing increasing potential to be alternatives for T₁-weighted magnetic resonance imaging (MRI) and contribute to the safety of gadolinium-based compounds. In this work, three water-soluble iron-based complexes constructed using catechol ligands exhibiting T₁-weighted MRI contrast behavior are described. The longitudinal relaxivity (r₁) increase from 0.88 to 1.43 mM⁻¹ s⁻¹ mainly depends on the sizes and the number of water molecules in the second and outer spheres around the discrete complexes.

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Article information

DOI: https://doi.org/10.1039/D0TB02716B
Article type: Communication
Submitted: 21 Nov 2020
Accepted: 28 Jan 2021
First published: 03 Feb 2021

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J. Mater. Chem. B, 2021,9, 1787-1791

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A class of water-soluble Fe(III) coordination complexes as T₁-weighted MRI contrast agents

R. Wang, L. An, J. He, M. Li, J. Jiao and S. Yang, J. Mater. Chem. B, 2021, 9, 1787 DOI: 10.1039/D0TB02716B

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Journal of Materials Chemistry B