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Issue 13, 2021
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Aggregation-free and high stability core–shell polymer nanoparticles with high fullerene loading capacity, variable fullerene type, and compatibility towards biological conditions

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Abstract

Fullerenes have unique structural and electronic properties that make them attractive candidates for diagnostic, therapeutic, and theranostic applications. However, their poor water solubility remains a limiting factor in realizing their full biomedical potential. Here, we present an approach based on a combination of supramolecular and covalent chemistry to access well-defined fullerene-containing polymer nanoparticles with a core–shell structure. In this approach, solvophobic forces and aromatic interactions first come into play to afford a micellar structure with a poly(ethylene glycol) shell and a corannulene-based fullerene-rich core. Covalent stabilization of the supramolecular assembly then affords core-crosslinked polymer nanoparticles. The shell makes these nanoparticles biocompatible and allows them to be dried to a solid and redispersed in water without inducing interparticle aggregation. The core allows a high content of different fullerene types to be encapsulated. Finally, covalent stabilization endows nanostructures with stability against changing environmental conditions.

Graphical abstract: Aggregation-free and high stability core–shell polymer nanoparticles with high fullerene loading capacity, variable fullerene type, and compatibility towards biological conditions

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Article information


Submitted
01 Feb 2021
Accepted
23 Feb 2021
First published
24 Feb 2021

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2021,12, 4949-4957
Article type
Edge Article

Aggregation-free and high stability core–shell polymer nanoparticles with high fullerene loading capacity, variable fullerene type, and compatibility towards biological conditions

T. Eom, V. Barát, A. Khan and M. C. Stuparu, Chem. Sci., 2021, 12, 4949
DOI: 10.1039/D1SC00602A

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

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    [Original citation] - Published by The Royal Society of Chemistry.

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