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Issue 4, 2021
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A pyrone remodeling strategy to access diverse heterocycles: application to the synthesis of fascaplysin natural products

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Abstract

The synthesis of diverse N-fused heterocycles, including the pyrido[1,2-a]indole scaffold, using an efficient pyrone remodeling strategy is described. The pyrido[1,2-a]indole core was demonstrated to be a versatile scaffold that can be site-selectively functionalized. The utility of this novel annulation strategy was showcased in a concise formal synthesis of three fascaplysin congeners.

Graphical abstract: A pyrone remodeling strategy to access diverse heterocycles: application to the synthesis of fascaplysin natural products

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Supplementary files

Article information


Submitted
17 Nov 2020
Accepted
26 Nov 2020
First published
27 Nov 2020

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2021,12, 1528-1534
Article type
Edge Article

A pyrone remodeling strategy to access diverse heterocycles: application to the synthesis of fascaplysin natural products

V. Palani, M. A. Perea, K. E. Gardner and R. Sarpong, Chem. Sci., 2021, 12, 1528
DOI: 10.1039/D0SC06317G

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