Issue 4, 2021

A pyrone remodeling strategy to access diverse heterocycles: application to the synthesis of fascaplysin natural products

Abstract

The synthesis of diverse N-fused heterocycles, including the pyrido[1,2-a]indole scaffold, using an efficient pyrone remodeling strategy is described. The pyrido[1,2-a]indole core was demonstrated to be a versatile scaffold that can be site-selectively functionalized. The utility of this novel annulation strategy was showcased in a concise formal synthesis of three fascaplysin congeners.

Graphical abstract: A pyrone remodeling strategy to access diverse heterocycles: application to the synthesis of fascaplysin natural products

Supplementary files

Article information

Article type
Edge Article
Submitted
17 Nov 2020
Accepted
26 Nov 2020
First published
27 Nov 2020
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2021,12, 1528-1534

A pyrone remodeling strategy to access diverse heterocycles: application to the synthesis of fascaplysin natural products

V. Palani, M. A. Perea, K. E. Gardner and R. Sarpong, Chem. Sci., 2021, 12, 1528 DOI: 10.1039/D0SC06317G

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