Issue 47, 2021, Issue in Progress

Visible-light-driven cascade radical cyclization toward the synthesis of α-carbonyl alkyl-substituted benzimidazo[2,1-a]isoquinolin-6(5H)-one derivatives

Abstract

A visible-light-driven cascade radical cyclization process of N-methacryloyl-2-phenylbenzimidazole has been established with α-carbonyl alkyl bromide. This protocol provides an efficient and practical method for the synthesis of various α-carbonyl alkyl-substituted benzimidazo[2,1-α]isoquinolin-6(5H)-ones in outstanding yields, mild reaction conditions and excellent functional group tolerance.

Graphical abstract: Visible-light-driven cascade radical cyclization toward the synthesis of α-carbonyl alkyl-substituted benzimidazo[2,1-a]isoquinolin-6(5H)-one derivatives

Supplementary files

Article information

Article type
Paper
Submitted
05 Aug 2021
Accepted
24 Aug 2021
First published
01 Sep 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 29372-29375

Visible-light-driven cascade radical cyclization toward the synthesis of α-carbonyl alkyl-substituted benzimidazo[2,1-a]isoquinolin-6(5H)-one derivatives

J. Liu, H. Huang, C. Wang, Y. Li, H. Li, H. Hu, S. He, H. Tang and F. Gao, RSC Adv., 2021, 11, 29372 DOI: 10.1039/D1RA05936J

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