Access to 6-hydroxy indolizines and related imidazo[1,5-a]pyridines through the SN2 substitution/condensation/tautomerization cascade process

Guiyun Duan; Hao Liu; Liqing Zhang; Chunhao Yuan; Yongchao Li; Yanqing Ge

doi:10.1039/D1RA04425G

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Access to 6-hydroxy indolizines and related imidazo[1,5-a]pyridines through the S_N2 substitution/condensation/tautomerization cascade process†

Guiyun Duan,‡^a Hao Liu,‡^a Liqing Zhang,^a Chunhao Yuan,

^a Yongchao Li^a and Yanqing Ge

*^a

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* Corresponding authors

^a Department of Pharmacy, Shandong First Medical University, Shandong Academy of Medical Sciences, Taian, Shandong 271016, P. R. China
E-mail: geyanqing2016@126.com
Fax: +86-538-6229741
Tel: +86-538-6229741

Abstract

A simple and efficient cascade reaction was developed for the construction of hydroxy substituted indolizines from pyrrole-2-carbaldehydes and commercially available 4-halogenated acetoacetic esters. Their optical properties were also evaluated.

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DOI: https://doi.org/10.1039/D1RA04425G
Article type: Paper
Submitted: 08 Jun 2021
Accepted: 19 Jul 2021
First published: 23 Jul 2021
This article is Open Access

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RSC Adv., 2021,11, 25624-25627

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Access to 6-hydroxy indolizines and related imidazo[1,5-a]pyridines through the S_N2 substitution/condensation/tautomerization cascade process

G. Duan, H. Liu, L. Zhang, C. Yuan, Y. Li and Y. Ge, RSC Adv., 2021, 11, 25624 DOI: 10.1039/D1RA04425G

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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