Issue 38, 2021

The role of β-hairpin conformation in ester hydrolysis peptide catalysts based on a TrpZip scaffold

Abstract

To explore the role of peptide conformation on catalytic activity in the context of ester hydrolysis catalysts, pairs of sequences were designed that contained or lacked β-hairpin character. For the hydrolysis of para-nitrophenylacetate in aqueous media, we found small but consistent trends wherein His-containing sequences based on a TrpZip scaffold showed higher catalytic activity without β-hairpin character.

Graphical abstract: The role of β-hairpin conformation in ester hydrolysis peptide catalysts based on a TrpZip scaffold

Supplementary files

Article information

Article type
Paper
Submitted
02 Jun 2021
Accepted
24 Jun 2021
First published
06 Jul 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 23714-23718

The role of β-hairpin conformation in ester hydrolysis peptide catalysts based on a TrpZip scaffold

X. Liu, R. Waters, H. E. Gilbert, G. T. Barroso, K. M. Boyle and L. S. Witus, RSC Adv., 2021, 11, 23714 DOI: 10.1039/D1RA04288B

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements