Theoretical calculation of the reactivity of α-imino thioesters indicates that they are very reactive substrates for Umpolung N-alkylation. In fact, treatment of α-aldimino thioesters with dialkylzinc reagents in the presence of aldehydes or imines gives three-component coupling products in good yields.
M. Shimizu, A. Higashino, I. Mizota and Y. Zhu, RSC Adv., 2021, 11, 13097 DOI: 10.1039/D1RA02000E
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