Issue 22, 2021, Issue in Progress

Palladium-catalyzed one-pot synthesis of 2-substituted quinazolin-4(3H)-ones from o-nitrobenzamide and alcohols

Abstract

Palladium-catalyzed 2-substituted quinazolin-4(3H)-one formation from readily available o-nitrobenzamides and alcohols using hydrogen transfer is described. Various quinazolin-4(3H)-ones were obtained in good to high yields. The cascade reaction including alcohol oxidation, nitro reduction, condensation, and dehydrogenation occurs without any added reducing or oxidizing agent.

Graphical abstract: Palladium-catalyzed one-pot synthesis of 2-substituted quinazolin-4(3H)-ones from o-nitrobenzamide and alcohols

Supplementary files

Article information

Article type
Paper
Submitted
05 Mar 2021
Accepted
31 Mar 2021
First published
07 Apr 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 13119-13123

Palladium-catalyzed one-pot synthesis of 2-substituted quinazolin-4(3H)-ones from o-nitrobenzamide and alcohols

K. Wang, H. Chen, X. Dai, X. Huang and Z. Feng, RSC Adv., 2021, 11, 13119 DOI: 10.1039/D1RA01755A

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