Issue 22, 2021
From the journal:

RSC Advances

Dual-signal lateral flow assay using vancomycin-modified nanotags for rapid and sensitive detection of Staphylococcus aureus†

Shu Wang,‡ab   Wanzhu Shen,‡cd   Shuai Zheng,cd   Zhigang Li,a   Chongwen Wang, ORCID logo *cd   Long Zhang*ab  and  Yong Liu*ab  

* Corresponding authors

a Hefei Institute of Physical Science, Chinese Academy of Sciences, Hefei 230036, PR China
E-mail: liuyong@aiofm.ac.cn, zhanglong@aiofm.ac.cn, wangchongwen1987@126.com

b University of Science and Technology of China, Hefei 230036, PR China

c Anhui Agricultural University, Hefei 230036, PR China

d Beijing Institute of Radiation Medicine, Beijing 100850, PR China

Abstract

This paper reports a colorimetric-fluorescent dual-signal lateral flow assay (LFA) based on vancomycin (Van)-modified SiO2–Au-QD tags for sensitive and quantitative detection of Staphylococcus aureus (S. aureus). The combination of high-performance Van-tags and detection antibodies integrated into the LFA system produced assays with high sensitivity and specificity. The visualization limit of the colorimetric signal and the detection limit of the fluorescence signal of the proposed method for S. aureus can reach 104 and 100 cells mL−1, respectively.

Graphical abstract: Dual-signal lateral flow assay using vancomycin-modified nanotags for rapid and sensitive detection of Staphylococcus aureus

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Article information

DOI
https://doi.org/10.1039/D1RA01085A
Article type
Paper
Submitted
09 Feb 2021
Accepted
28 Mar 2021
First published
09 Apr 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 13297-13303

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Dual-signal lateral flow assay using vancomycin-modified nanotags for rapid and sensitive detection of Staphylococcus aureus

S. Wang, W. Shen, S. Zheng, Z. Li, C. Wang, L. Zhang and Y. Liu, RSC Adv., 2021, 11, 13297 DOI: 10.1039/D1RA01085A

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