A new and efficient lactic acid polymerization by multimetallic cerium complexes: a poly(lactic acid) suitable for biomedical applications

Abstract

Among many, poly(lactic acid) (PLA) has received significant consideration. The striking price and accessibility of L-lactic acid, as a naturally occurring organic acid, are important reasons for poly-(L)-lactic acid (PLLA) improvement. PLLA is a compostable and biocompatible/bioresorbable polymer used for disposable products, for biomedical applications, for packaging film, in the automotive industry, for electronic device components, and for many other applications. Formerly, titanium and other metals have been used in different orthopaedic screws and plates, but they are not degradable and therefore remain in the body. So, the development of innovative and eco compatible catalysts for polyester synthesis is of great interest. In this study, an innovative and eco sustainable catalyst was employed for PLLA synthesis. The combined CeCl₃·7H₂O–NaI system has been demonstrated to be a very valuable and nontoxic catalyst toward PLLA synthesis, and it represents a further example of how to exploit the antibacterial properties of cerium ions in biomaterials engineering. A novel synthesis of poly-(L)-lactic acid was developed in high yields up to 95% conversion and with a truly valuable molecular weight ranging from 9000 to 145 000 g mol⁻¹, testing different synthetic routes.