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Issue 13, 2021, Issue in Progress

A simple approach to prepare fluorescent molecularly imprinted nanoparticles

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Abstract

Fluorescent molecularly imprinted polymers (FMIPs) are gaining increasing attention in analytical and medical sciences, particularly silica-based FMIPs due to their low cost, environmentally friendly nature and good biocompatibility. However, at present, silica-based FMIPs are usually prepared through several steps and displayed low selectivity. Here, a simple approach was utilized for preparing silica-based FMIP nanoparticles. The polymerization was initiated by 3-aminopropyltriethoxysilane (APTES), which also acted as the functional monomer in the imprinting system; in addition, to achieve one-pot synthesis, a fluorescent monomer was prepared by a simple reaction between fluorescein isothiocyanate (FITC) and APTES. The as-synthesized FMIP nanoparticles displayed high specificity and fast response time (<1 min) towards the target molecule. Environmental pH and buffer salt could affect the specific recognition behaviors of the FMIP nanoparticles. Such a simple catalyst-free synthetic technique could also be employed for the preparation of FMIP nanoparticles targeting other acidic molecules.

Graphical abstract: A simple approach to prepare fluorescent molecularly imprinted nanoparticles

Supplementary files

Article information


Submitted
17 Dec 2020
Accepted
26 Jan 2021
First published
17 Feb 2021

This article is Open Access

RSC Adv., 2021,11, 7732-7737
Article type
Paper

A simple approach to prepare fluorescent molecularly imprinted nanoparticles

F. Wang, D. Wang, T. Wang, Y. Jin, B. Ling, Q. Li and J. Li, RSC Adv., 2021, 11, 7732 DOI: 10.1039/D0RA10618F

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