Novel albumin-binding photothermal agent ICG-IBA-RGD for targeted fluorescent imaging and photothermal therapy of cancer

Cheng Yu; Enhua Xiao; Pengfei Xu; Jingjing Lin; Linan Hu; Jie Zhang; Shengzhen Dai; Zhuyuan Ding; Yuyang Xiao; Zhu Chen

doi:10.1039/D0RA09653A

Novel albumin-binding photothermal agent ICG-IBA-RGD for targeted fluorescent imaging and photothermal therapy of cancer†

Cheng Yu,

^a Enhua Xiao,^a Pengfei Xu,

^c Jingjing Lin,^b Linan Hu,^a Jie Zhang,^a Shengzhen Dai,^a Zhuyuan Ding,^a Yuyang Xiao^a and Zhu Chen*^a

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* Corresponding authors

^a Departments of Radiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P. R. China
E-mail: chenzhu415@csu.edu.cn

^b Department of Psychiatry, The Second Xiangya Hospital, Central South University, National Clinical Research Center for Mental Disorders, Hunan Medical Center for Mental Health, Changsha, Hunan 410011, P. R. China

^c Institute of Clinical Pharmacy & Pharmacology, Jining First People's Hospital, Jining Medical University, Jining 272000, P. R. China

Abstract

In this work, we present a novel photothermal agent ICG-IBA-RGD based on albumin-binding strategy for enhanced tumor targeting imaging and photothermal therapy. In vitro and in vivo experiments demonstrated that ICG-IBA-RGD exhibits excellent photothermal conversion capability and high tumor ablation efficiency.

RSC Advances

Novel albumin-binding photothermal agent ICG-IBA-RGD for targeted fluorescent imaging and photothermal therapy of cancer†

Abstract

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Novel albumin-binding photothermal agent ICG-IBA-RGD for targeted fluorescent imaging and photothermal therapy of cancer

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